What is the primary disorder associated with the death of dopamine neurons in the substantia nigra?

Parkinson's Disease is primarily associated with the death of dopamine neurons in the substantia nigra, a critical area of the brain that plays an essential role in movement control. The substantia nigra is part of the basal ganglia, which is involved in the regulation of voluntary movements. The loss of dopamine-producing neurons in this region leads to a reduction in dopamine levels, contributing to the motor symptoms characteristic of Parkinson's Disease, such as tremors, rigidity, bradykinesia, and postural instability.

The other disorders listed do not specifically involve the degeneration of dopamine neurons in the substantia nigra. Multiple Sclerosis is an autoimmune disease that primarily affects the myelin sheath of neurons and does not target specific neurotransmitter systems. Alzheimer's Disease is associated with the loss of acetylcholine neurons in certain areas of the brain and is primarily linked to memory loss and cognitive decline rather than motor function. Huntington's Disease involves genetic mutations that lead to the degeneration of neurons in specific areas of the brain, but it does not specifically target dopamine neurons in the substantia nigra as seen in Parkinson's Disease.