Which substances are known to increase pain sensitivity?

Prostaglandins are compounds that are synthesized in response to injury or inflammation and play a significant role in increasing pain sensitivity. When tissues are damaged, prostaglandins are released, which sensitize nerve endings and enhance the perception of pain. This process helps signal to the body that there is an injury that needs attention, contributing to the protective response to avoid further damage.

In contrast, endorphins function as natural pain relievers in the body, helping to reduce pain sensation, while dopamine and serotonin are neurotransmitters involved in mood regulation and various neurological functions, but they do not have a direct role in increasing pain sensitivity.